Comparative analysis of fungal protein kinases and associated domains.

ABSTRACT:

Background

Protein phosphorylation is responsible for a large portion of the regulatory functions of eukaryotic cells. Although the list of sequenced genomes of filamentous fungi has grown rapidly, the kinomes of recently sequenced species have not yet been studied in detail. The objective of this study is to apply a comparative analysis of the kinase distribution in different fungal phyla, and to explore its relevance to understanding the evolution of fungi and their taxonomic classification. We have analyzed in detail 12 subgroups of kinases and their distribution over 30 species, as well as their potential use as a classifier for members of the fungal kingdom.

Results

Our findings show that despite the similarity of the kinase distribution in all fungi, their domain distr

SUBMITTER: Kosti I 

PROVIDER: S-EPMC2838846 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature