Distribution of candidate genes for experimentally induced arthritis in rats.

ABSTRACT:

Background

Rat models are frequently used to link genomic regions to experimentally induced arthritis in quantitative trait locus (QTL) analyses. To facilitate the search for candidate genes within such regions, we have previously developed an application (CGC) that uses weighted keywords to rank genes based on their descriptive text. In this study, CGC is used for analyzing the localization of candidate genes from two viewpoints: distribution over the rat genome and functional connections between arthritis QTLs.

Methods

To investigate if candidate genes identified by CGC are more likely to be found inside QTLs, we ranked 2403 genes genome wide in rat. The number of genes within different ranges of CGC scores localized inside and outside QTLs was then calculated. Furthermore

SUBMITTER: Andersson L 

PROVIDER: S-EPMC2838850 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature