Kinetics of serum cytokines after primary or repeat vaccination with the smallpox vaccine.

ABSTRACT:

Background

The smallpox vaccine is associated with more serious adverse events than any other live attenuated vaccine in use today. Although studies have examined serum cytokine levels in primary vaccine recipients at 1 and 3-5 weeks after vaccination with the smallpox vaccine, serial measurements have not been performed, and studies in revaccinated subjects have not been conducted.

Methods

We analyzed cytokine responses in both primary vaccine recipients and revaccinated subjects every other day for 2 weeks after vaccination.

Results

Primary vaccine recipients had maximal levels of granulocyte-colony-stimulating factor on days 6-7 after vaccination; peak levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptor 1, interferon (IFN)-gamma, IFN-inducible protein

SUBMITTER: Cohen JI 

PROVIDER: S-EPMC2839010 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature