Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB.

ABSTRACT:

Objective

To investigate whether longitudinal declines in cognition are associated with higher fibrillar amyloid-beta (Abeta) deposition in vivo in individuals without dementia.

Method

[(11)C]PiB images were obtained to measure fibrillar Abeta burden in 57 participants without dementia from the Baltimore Longitudinal Study of Aging. Participants (33 men, 24 women) had a mean (SD) age of 78.7 (6.2) years. Six participants (4 men, 2 women) had mild cognitive impairment defined as Clinical Dementia Rating = 0.5. To measure [(11)C]PiB retention, distribution volume ratios (DVR) for 15 regions of interest were estimated by fitting a simplified reference tissue model to the measured time activity curves. Mixed effects regression was used to predict cognitive trajectories over time

SUBMITTER: Resnick SM 

PROVIDER: S-EPMC2839197 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature