The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments.

ABSTRACT:

Background

EV71 occasionally cause a series of severe neurological symptoms, including aseptic meningitis, encephalitis, and poliomyelitis-like paralysis. However, the neurological destruction mechanism was remained to be clarified. This study described the cross reaction between EV71 induced IgG and human brain tissue.

Results

Cross reaction of the IgG from 30 EV71 infected patients' sera to human tissues of cerebra was observed, which suggested that some EV71 antigens could induce IgG cross-reactivity to human cerebra. To identify the regions of EV71 virus that containing above antigens, the polypeptide of virus was divided into 19 peptides by expression in prokaryotes cell. Mouse anti-sera of these peptides was prepared and applied in immunohistochemical staining with hum

SUBMITTER: Jia CS 

PROVIDER: S-EPMC2839975 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature