Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is characterized by late detection and fast progression, and it is believed that epigenetic disruption may be the cause of its molecular and clinicopathological heterogeneity. A better understanding of the global deregulation of methylation states and how they correlate with disease progression will aid in the design of strategies for earlier detection and better therapeutic decisions.

Methods and findings

We characterized the changes in promoter methylation in a series of 30 HCC tumors and their respective surrounding tissue and identified methylation signatures associated with major risk factors and clinical correlates. A wide panel of cancer-related gene promoters was analyzed using Illumina bead array technology, and CpG sites we

SUBMITTER: Hernandez-Vargas H 

PROVIDER: S-EPMC2840036 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature