Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae.

ABSTRACT: A systematic functional analysis across much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xenopus oocytes using two-electrode, voltage-clamp electrophysiology. The resulting data indicate that each AgOR manifests a distinct odor-response profile and tuning breadth. The large diversity of tuning responses ranges from AgORs that are responsive to a single or small number of odorants (specialists) to more broadly tuned receptors (generalists). Several AgORs were identified that respond robustly to a range of human volatiles that may play a critical role in anopheline host selection. AgOR responses were analyzed further by constructing a multidimensional odor space representing the relationships between odorants and AgOR responses. Within this spa

SUBMITTER: Wang G 

PROVIDER: S-EPMC2840125 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature