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Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis.


ABSTRACT: D-aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development and survival of newborn neurons and survival. Because D-aspartate is a potential endogenous ligand for NMDA receptors, the loss of which elicits a phenotype resembling DR depletion, D-aspartate may function as a modulator of adult neurogenesis.

SUBMITTER: Kim PM 

PROVIDER: S-EPMC2840285 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis.

Kim Paul M PM   Duan Xin X   Huang Alex S AS   Liu Cindy Y CY   Ming Guo-li GL   Song Hongjun H   Snyder Solomon H SH  

Proceedings of the National Academy of Sciences of the United States of America 20100126 7


D-aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development and survival of newborn neurons and survival. Because D-aspartate is a potential endogenous ligan  ...[more]

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