Ontology highlight
ABSTRACT:
SUBMITTER: Kim PM
PROVIDER: S-EPMC2840285 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Kim Paul M PM Duan Xin X Huang Alex S AS Liu Cindy Y CY Ming Guo-li GL Song Hongjun H Snyder Solomon H SH
Proceedings of the National Academy of Sciences of the United States of America 20100126 7
D-aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development and survival of newborn neurons and survival. Because D-aspartate is a potential endogenous ligan ...[more]