Shared and distinct genetic variants in type 1 diabetes and celiac disease.

ABSTRACT:

Background

Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared.

Methods

We evaluated the association between type 1 diabetes and eight loci related to the risk of celiac disease by genotyping and statistical analyses of DNA samples from 8064 patients with type 1 diabetes, 9339 control subjects, and 2828 families providing 3064 parent-child trios (consisting of an affected child and both biologic parents). We also investigated 18 loci associated with type 1 diabetes in 2560 patients with celiac disease and 9339 control subjects.

Results

Three celiac disease loci--RGS1 on

SUBMITTER: Smyth DJ 

PROVIDER: S-EPMC2840835 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature