Serotonin transport and metabolism in the mammary gland modulates secretory activation and involution.

ABSTRACT:

Context

Serotonin [5-hydroxytryptamine (5-HT)] is an important local regulator of lactation homeostasis; however, the roles for the serotonin reuptake transporter and monoamine oxidase have not been known.

Objective

The aim of the study was to determine whether drugs that impact 5-HT affect human lactation physiology.

Design and setting

We conducted laboratory studies of human and animal models and an observational study of the onset of copious milk secretion in postpartum women at a university medical center.

Participants

We studied women expecting their first live-born infant; exclusion criteria were: referred to the medical center for another medical condition, known contraindication to breastfeed, and less than 19 yr of age and unable to obtain parental con

SUBMITTER: Marshall AM 

PROVIDER: S-EPMC2840848 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature