Identification and in vitro characterization of follicle stimulating hormone (FSH) receptor variants associated with abnormal ovarian response to FSH.

ABSTRACT:

Context

FSH mediates cyclic follicle growth and development and is widely used for controlled ovarian stimulation in women undergoing infertility treatment. The ovarian response of women to FSH is variable, ranging from poor response to ovarian hyperstimulation.

Objective

We investigated whether genetic alterations of the FSH receptor (FSHR) contribute to this variability.

Design and patients

Our approach was to study women undergoing treatment with in vitro fertilization falling into the edges of the normal distribution of ovarian response to FSH, with respect to age.

Setting

We conducted the study at the Yale Fertility Clinic.

Methods

We extracted RNA from cumulus cells surrounding the oocytes of women undergoing in vitro fertilization and analyzed the

SUBMITTER: Gerasimova T 

PROVIDER: S-EPMC2840851 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature