Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status.

ABSTRACT:

Background

Being overweight or obese is an established risk factor for colorectal cancer, more so for men than for women. Approximately 10%-20% of colorectal tumors display microsatellite instability (MSI), defined as the expansion or contraction of small repeated sequences in the DNA of tumor tissue relative to nearby normal tissue. We evaluated associations between overweight or obesity and colorectal cancer risk, overall and by tumor MSI status.

Methods

The study included 1794 case subjects with incident colorectal cancer who were identified through population-based cancer registries and 2684 of their unaffected sex-matched siblings as control subjects. Recent body mass index (BMI), BMI at age 20 years, and adult weight change were derived from self-reports of height and

SUBMITTER: Campbell PT 

PROVIDER: S-EPMC2841037 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature