Microarray-based gene expression profiling and DNA copy number variation analysis of temporal fossa arachnoid cysts.

ABSTRACT:

Background

Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the temporal fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes.

Methods

In order to identify differences in gene expression between normal arachnoid membrane (AM) and cyst membrane, we have performed a high-resolution mRNA microarray analysis. In addition we have screened DNA from AC samples for chromosomal duplications or deletions using DNA microarray-based copy number variation analysis.

Results

The transcriptome consisting of 33096 gene probes showed a near-complete similarity in expression between AC and AM sampl

SUBMITTER: Aarhus M 

PROVIDER: S-EPMC2841093 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature