Conservation and divergence of known apicomplexan transcriptional regulons.

ABSTRACT:

Background

The apicomplexans are a diverse phylum of parasites causing an assortment of diseases including malaria in a wide variety of animals and lymphoproliferation in cattle. Little is known about how these varied parasites regulate their transcriptional regulons. Even less is known about how regulon systems, consisting of transcription factors and target genes together with their associated biological process, evolve in these diverse parasites.

Results

In order to obtain insights into the differences in transcriptional regulation between these parasites we compared the orthology profiles of putative malaria transcription factors across species and examined the enrichment patterns of four binding sites across eleven apicomplexans. About three-fifths of the factors are br

SUBMITTER: Essien K 

PROVIDER: S-EPMC2841118 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature