Dataset Information
Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study.
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ABSTRACT:
SUBMITTER: Su TI
PROVIDER: S-EPMC2841149 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study.
Arthritis and rheumatism 20091201 12
<h4>Objective</h4>To assess the safety and efficacy of rapamycin in the treatment of diffuse systemic sclerosis (SSc; scleroderma).<h4>Methods</h4>Eighteen patients with diffuse SSc of <or=5 years duration were randomized to receive rapamycin or methotrexate (MTX) in a single-blind, 48-week study. Abnormalities in clinical and laboratory parameters were compared between the 2 treatment groups. The potential efficacy of the study drugs was evaluated by comparing results of the baseline and 48-wee ...[more]
