The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms.

ABSTRACT:

Background

We compare the genotype distribution for the serotonin transporter polymorphism (5-HTTLPR) in a sample of older Taiwanese adults with samples of various racial and ethnic groups collected in other studies. We also explore interactions among sex, stressors, and 5-HTTLPR genotype on depressive symptoms in our sample.

Methods

Using a nationally representative sample of 984 Taiwanese aged 53 and older, we model depressive symptoms as a function of 5-HTTLPR genotype and two classes of stressors: lifetime trauma and recent major life events. We test two- and three-way interactions among stressors, 5-HTTLPR, and sex.

Results

This sample exhibits higher frequency of S/S and lower frequency of L/L genotype than Western samples, but the distribution is comparable to

SUBMITTER: Goldman N 

PROVIDER: S-EPMC2841212 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature