GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.

ABSTRACT: Chromosomal double-strand breaks (DSBs) are considered to be among the most deleterious DNA lesions found in eukaryotic cells due to their propensity to promote genome instability. DSBs occur as a result of exogenous or endogenous DNA damage, and also occur during meiotic recombination. DSBs are often repaired through a process called homologous recombination (HR), which employs the sister chromatid in mitotic cells or the homologous chromosome in meiotic cells, as a template for repair. HR frequently involves the formation and resolution of four-way DNA structures referred to as the Holliday junction (HJ). Despite extensive study, the machinery and mechanisms used to process these structures in eukaryotes have remained poorly understood. Recent work has identified XPG and UvrC/GIY domain-

SUBMITTER: Svendsen JM 

PROVIDER: S-EPMC2841330 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature