Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium.

ABSTRACT: Previous studies have shown that physiological responses to cigarette smoke can be detected via bronchial airway epithelium gene expression profiling and that heterogeneity in this gene expression response to smoking is associated with lung cancer. In this study, we sought to determine the similarity of the effects of tobacco smoke throughout the respiratory tract by determining patterns of smoking-related gene expression in paired nasal and bronchial epithelial brushings collected from 14 healthy nonsmokers and 13 healthy current smokers. Using whole genome expression arrays, we identified 119 genes whose expression was affected by smoking similarly in both bronchial and nasal epithelium, including genes related to detoxification, oxidative stress, and wound healing. While the vast majori

SUBMITTER: Zhang X 

PROVIDER: S-EPMC2841495 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature