Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum.

ABSTRACT:

Background

Leptospirosis is a zoonosis of worldwide distribution caused by infection with pathogenic serovars of Leptospira spp. The most common species, L. interrogans, can survive in the environment for lengthy periods of time in between infection of mammalian hosts. Transmission of pathogenic Leptospira to humans mostly occurs through abraded skin or mucosal surfaces after direct or indirect contact with infected animals or contaminated soil or water. The spirochete then spreads hematogenously, resulting in multi-organ failure and death in severe cases. Previous DNA microarray studies have identified differentially expressed genes required for adaptation to temperature and osmolarity conditions inside the host compared to those of the environment.

Results

In order to iden

SUBMITTER: Patarakul K 

PROVIDER: S-EPMC2841595 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature