Structural classification by the Lipase Engineering Database: a case study of Candida antarctica lipase A.

ABSTRACT:

Background

The Lipase Engineering Database (LED) integrates information on sequence, structure and function of lipases, esterases and related proteins with the alpha/beta hydrolase fold. A new superfamily for Candida antarctica lipase A (CALA) was introduced including the recently published crystal structure of CALA. Since CALA has a highly divergent sequence in comparison to other alpha/beta hydrolases, the Lipase Engineering Database was used to classify CALA in the frame of the already established classification system. This involved the comparison of CALA to similar structures as well as sequence-based comparisons against the content of the LED.

Results

The new release 3.0 (December 2009) of the Lipase Engineering Database contains 24783 sequence entries for 18585 protei

SUBMITTER: Widmann M 

PROVIDER: S-EPMC2841678 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature