Genome-wide transcription factor binding site/promoter databases for the analysis of gene sets and co-occurrence of transcription factor binding motifs.

ABSTRACT:

Background

The use of global gene expression profiling is a well established approach to understand biological processes. One of the major goals of these investigations is to identify sets of genes with similar expression patterns. Such gene signatures may be very informative and reveal new aspects of particular biological processes. A logical and systematic next step is to reduce the identified gene signatures to the regulatory components that induce the relevant gene expression changes. A central issue in this context is to identify transcription factors, or transcription factor binding sites (TFBS), likely to be of importance for the expression of the gene signatures.

Results

We develop a strategy that efficiently produces TFBS/promoter databases based on user-defined cri

SUBMITTER: Veerla S 

PROVIDER: S-EPMC2841680 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature