Polygenic and directional regulatory evolution across pathways in Saccharomyces.

ABSTRACT: The search to understand how genomes innovate in response to selection dominates the field of evolutionary biology. Powerful molecular evolution approaches have been developed to test individual loci for signatures of selection. In many cases, however, an organism's response to changes in selective pressure may be mediated by multiple genes, whose products function together in a cellular process or pathway. Here we assess the prevalence of polygenic evolution in pathways in the yeasts Saccharomyces cerevisiae and S. bayanus. We first established short-read sequencing methods to detect cis-regulatory variation in a diploid hybrid between the species. We then tested for the scenario in which selective pressure in one species to increase or decrease the activity of a pathway has driven the ac

SUBMITTER: Bullard JH 

PROVIDER: S-EPMC2841874 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature