Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

ABSTRACT: Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered gammaretrovirus that has been linked to prostate cancer and chronic fatigue syndrome. This virus is therefore an important potential human pathogen and, as such, it is essential to understand its host cell tropism. Intriguingly, infectious virus has been recovered from patient-derived peripheral blood mononuclear cells. These cells express several antiviral restriction factors that are capable of inhibiting the replication of a wide range of retroviruses, including other gamma retroviruses. This raises the possibility that, similar to HIV, XMRV may have acquired resistance to restriction. We therefore investigated the susceptibility of XMRV to a panel of different restriction factors. We found that both human AP

SUBMITTER: Groom HC 

PROVIDER: S-EPMC2841911 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature