Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus.

ABSTRACT: Relatively little is understood about the dynamics of global host-pathogen transcriptome changes that occur during bacterial infection of mucosal surfaces. To test the hypothesis that group A Streptococcus (GAS) infection of the oropharynx provokes a distinct host transcriptome response, we performed genome-wide transcriptome analysis using a nonhuman primate model of experimental pharyngitis. We also identified host and pathogen biological processes and individual host and pathogen gene pairs with correlated patterns of expression, suggesting interaction. For this study, 509 host genes and seven biological pathways were differentially expressed throughout the entire 32-day infection cycle. GAS infection produced an initial widespread significant decrease in expression of many host genes,

SUBMITTER: Shea PR 

PROVIDER: S-EPMC2842040 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature