Mutation-selection models of coding sequence evolution with site-heterogeneous amino acid fitness profiles.

ABSTRACT: Modeling the interplay between mutation and selection at the molecular level is key to evolutionary studies. To this end, codon-based evolutionary models have been proposed as pertinent means of studying long-range evolutionary patterns and are widely used. However, these approaches have not yet consolidated results from amino acid level phylogenetic studies showing that selection acting on proteins displays strong site-specific effects, which translate into heterogeneous amino acid propensities across the columns of alignments; related codon-level studies have instead focused on either modeling a single selective context for all codon columns, or a separate selective context for each codon column, with the former strategy deemed too simplistic and the latter deemed overparameterized. Here

SUBMITTER: Rodrigue N 

PROVIDER: S-EPMC2842053 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature