Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study.

ABSTRACT:

Objective

Our goal is to determine if antimicrobial prophylaxis with trimethoprim/sulfamethoxazole prevents recurrent urinary tract infections and renal scarring in children who are found to have vesicoureteral reflux after a first or second urinary tract infection.

Design, participants, and methods

The Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study is a double-blind, randomized, placebo-controlled trial. Six hundred children aged 2 to 72 months will be recruited from both primary and subspecialty care settings at clinical trial centers throughout North America. Children who are found to have grades I to IV vesicoureteral reflux after the index febrile or symptomatic urinary tract infection will be randomly assigned to receive daily doses of ei

SUBMITTER: Keren R 

PROVIDER: S-EPMC2842127 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature