A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion.

ABSTRACT:

Background

Glioblastoma multiforme (GBM, WHO grade IV) is the most common and most malignant of astrocytic brain tumors, and is associated with rapid invasion into neighboring tissue. In other tumor types it is well established that such invasion involves a complex interaction between tumor cells and locally produced extracellular matrix. In GBMs, surprisingly little is known about the associated matrix components, in particular the fibrillar proteins such as collagens that are known to play a key role in the invasion of other tumor types.

Methodology/principal findings

In this study we have used both the Masson's trichrome staining and a high resolution multiple immunofluorescence labeling method to demonstrate that intratumoral fibrillar collagens are an integral part of t

SUBMITTER: Huijbers IJ 

PROVIDER: S-EPMC2842440 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature