Surface-based analysis on shape and fractional anisotropy of white matter tracts in Alzheimer's disease.

ABSTRACT:

Background

White matter disruption has been suggested as one of anatomical features associated with Alzheimer's disease (AD). Diffusion tensor imaging (DTI), which has been widely used in AD studies, obtains new insights into the white matter structure.

Methods

We introduced surface-based geometric models of the deep white matter tracts extracted from DTI, allowing the characterization of their shape variations relative to an atlas as well as fractional anisotropy (FA) variations on the atlas surface through large deformation diffeomorphic metric mapping (LDDMM). We applied it to assess local shapes and FA variations of twenty-three deep white matter tracts in 13 patients with AD and 19 healthy control subjects.

Results

Our results showed regionally-specific shape abn

SUBMITTER: Qiu A 

PROVIDER: S-EPMC2842443 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature