Transmural dispersion of repolarization in failing and nonfailing human ventricle.

ABSTRACT:

Rationale

Transmural dispersion of repolarization has been shown to play a role in the genesis of ventricular tachycardia and fibrillation in different animal models of heart failure (HF). Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important contributor to the HF phenotype. However, there is limited electrophysiological data from the human heart.

Objective

To study electrophysiological remodeling of transmural repolarization in the failing and nonfailing human hearts.

Methods and results

We optically mapped the action potential duration (APD) in the coronary-perfused scar-free posterior-lateral left ventricular free wall wedge preparations from failing (n=5) and nonfailing (n=5) human hearts

SUBMITTER: Glukhov AV 

PROVIDER: S-EPMC2842469 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature