Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity.

ABSTRACT: The inferior olivary nuclei clearly play a role in creating oculopalatal tremor, but the exact mechanism is unknown. Oculopalatal tremor develops some time after a lesion in the brain that interrupts inhibition of the inferior olive by the deep cerebellar nuclei. Over time the inferior olive gradually becomes hypertrophic and its neurons enlarge developing abnormal soma-somatic gap junctions. However, results from several experimental studies have confounded the issue because they seem inconsistent with a role for the inferior olive in oculopalatal tremor, or because they ascribe the tremor to other brain areas. Here we look at 3D binocular eye movements in 15 oculopalatal tremor patients and compare their behaviour to the output of our recent mathematical model of oculopalatal tremor. Thi

SUBMITTER: Shaikh AG 

PROVIDER: S-EPMC2842510 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature