Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture.

ABSTRACT:

Background

Osteoporosis is a highly heritable trait. Many candidate genes have been proposed as being involved in regulating bone mineral density (BMD). Few of these findings have been replicated in independent studies.

Objective

To assess the relationship between BMD and fracture and all common single-nucleotide polymorphisms (SNPs) in previously proposed osteoporosis candidate genes.

Design

Large-scale meta-analysis of genome-wide association data.

Setting

5 international, multicenter, population-based studies.

Participants

Data on BMD were obtained from 19 195 participants (14 277 women) from 5 populations of European origin. Data on fracture were obtained from a prospective cohort (n = 5974) from the Netherlands.

Measurements

Systematic litera

SUBMITTER: Richards JB 

PROVIDER: S-EPMC2842981 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature