Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.

ABSTRACT:

Rationale

The genes encoding fibroblast growth factor (FGF) 8 and 10 are expressed in the anterior part of the second heart field that constitutes a population of cardiac progenitor cells contributing to the arterial pole of the heart. Previous studies of hypomorphic and conditional Fgf8 mutants show disrupted outflow tract (OFT) and right ventricle (RV) development, whereas Fgf10 mutants do not have detectable OFT defects.

Objectives

Our aim was to investigate functional overlap between Fgf8 and Fgf10 during formation of the arterial pole.

Methods and results

We generated mesodermal Fgf8; Fgf10 compound mutants with MesP1Cre. The OFT/RV morphology in these mutants was affected with variable penetrance; however, the incidence of embryos with severely affected OFT/RV m

SUBMITTER: Watanabe Y 

PROVIDER: S-EPMC2843098 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature