Silicon photonic microring resonators for quantitative cytokine detection and T-cell secretion analysis.

ABSTRACT: The ability to perform multiple simultaneous protein biomarker measurements in complex media with picomolar sensitivity presents a large challenge to disease diagnostics and fundamental biological studies. Silicon photonic microring resonators represent a promising platform for real-time detection of biomolecules on account of their spectral sensitivity toward surface binding events between a target and antibody-modified microrings. For all refractive index-based sensing schemes, the mass of bound analytes, in combination with other factors such as antibody affinity and surface density, contributes to the observed signal and measurement sensitivity. Therefore, proteins that are simultaneously low in abundance and have a lower molecular weight are often challenging to detect. By employing a

SUBMITTER: Luchansky MS 

PROVIDER: S-EPMC2843522 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature