Lifespan influences on mid- to late-life cognitive function in a Chinese birth cohort.

ABSTRACT:

Objective

To explore factors throughout the lifespan that influence cognition in midlife to late life.

Methods

We conducted a retrospective birth cohort study of 2,062 individuals born during 1921-1954 in Beijing, China. In 2003-2005, birth records were abstracted, and participants then 50-82 years old received standardized examinations for health, cognition, and socio-environmental measures. Using cumulative logit models, we assessed adjusted relative effects of prenatal, early life, and adult factors on mid- to late-life cognition.

Results

Most prenatal factors were associated with mid- to late-life cognition in the unadjusted models. However, when childhood and adult factors were sequentially added to the models, the impact of prenatal factors showed successive att

SUBMITTER: Zhang ZX 

PROVIDER: S-EPMC2843580 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature