Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease.

ABSTRACT:

Background

Oxidative stress is heavily implicated in the pathogenic process of Parkinson's disease. Varying capacity to detoxify radical oxygen species through induction of phase II antioxidant enzymes in substantia nigra may influence disease risk. Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's disease.

Methods

The study included a Swedish discovery case-control material (165 cases and 190 controls) and a Polish replication case-control material (192 cases and 192 controls). Eight tag single nucleotide polymorphisms representing the variation in NFE2L2 and three representing the variation in KEAP1 were chosen using HapMap data and were genotyped using TaqMan Al

SUBMITTER: von Otter M 

PROVIDER: S-EPMC2843602 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature