Genetic copy number variants in sib pairs both affected with schizophrenia.

ABSTRACT:

Background

Schizophrenia is a complex disorder with involvement of multiple genes.

Methods

In this study, genome-wide screening for DNA copy-number variations (CNVs) was conducted for ten pairs, a total of 20 cases, of affected siblings using oligonucleotide array-based CGH.

Results

We found negative symptoms were significantly more severe (p < 0.05) in the subgroup that harbored more genetic imbalance (n >== 13, n = number of CNV-disrupted genes) as compared with the subgroup with fewer CNVs (n <== 6), indicating that the degree of genetic imbalance may influence the severity of the negative symptoms of schizophrenia. Four central nervous system (CNS) related genes including CCAAT/enhancer binding protein, delta (CEBPD, 8q11.21), retinoid x receptor, alpha (RXRA, 9q3

SUBMITTER: Lee CH 

PROVIDER: S-EPMC2843606 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature