Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy.

ABSTRACT:

Background

Electrochemotherapy treats tumors by combining specific chemotherapeutic drugs with an intracellular target and electric pulses, which increases drug uptake into the tumor cells. Electrochemotherapy has been successfully used for treatment of easily accessible superficial tumor nodules. In this paper, we present the first case of deep-seated tumor electrochemotherapy based on numerical treatment planning.

Methods

The aim of our study was to treat a melanoma metastasis in the thigh of a patient. Treatment planning for electrode positioning and electrical pulse parameters was performed for two different electrode configurations: one with four and another with five long needle electrodes. During the procedure, the four electrode treatment plan was adopted and the pat

SUBMITTER: Miklavcic D 

PROVIDER: S-EPMC2843684 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature