Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area.

ABSTRACT:

Background

Transmission of malaria in West African urban areas is low and healthcare facilities are well organized. However, malaria mortality remains high. We conducted a survey in Dakar with the general objective to establish who died from severe malaria (SM) in urban areas (particularly looking at the age-groups) and to compare parasite isolates associated with mild or severe malaria.

Methodology/principal findings

The current study included mild- (MM) and severe malaria (SM) cases, treated in dispensaries (n = 2977) and hospitals (n = 104), We analysed Pfdhfr/Pfcrt-exon2 and nine microsatellite loci in 102 matched cases of SM and MM. Half of the malaria cases recorded at the dispensaries and 87% of SM cases referred to hospitals, occurred in adults, although adults only

SUBMITTER: Bob NS 

PROVIDER: S-EPMC2843705 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature