Adaptation of group A Streptococcus to human amniotic fluid.

ABSTRACT:

Background

For more than 100 years, group A Streptococcus has been identified as a cause of severe and, in many cases, fatal infections of the female urogenital tract. Due to advances in hospital hygiene and the advent of antibiotics, this type of infection has been virtually eradicated. However, within the last three decades there has been an increase in severe intra- and post-partum infections attributed to GAS.

Methodology

We hypothesized that GAS alters its transcriptome to survive in human amniotic fluid (AF) and cause disease. To identify genes that were up or down regulated in response to growth in AF, GAS was grown in human AF or standard laboratory media (THY) and samples for expression microarray analysis were collected during mid-logarithmic, late-logarithmic, and

SUBMITTER: Sitkiewicz I 

PROVIDER: S-EPMC2843714 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature