Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial.

ABSTRACT:

Background

Dietary recommendations for selenium differ between countries, mainly because of uncertainties over the definition of optimal selenium status.

Objective

The objective was to examine the dose-response relations for different forms of selenium.

Design

A randomized, double-blind, placebo-controlled dietary intervention was carried out in 119 healthy men and women aged 50-64 y living in the United Kingdom. Daily placebo or selenium-enriched yeast tablets containing 50, 100, or 200 microg Se ( approximately 60% selenomethionine), selenium-enriched onion meals ( approximately 66% gamma-glutamyl-methylselenocysteine, providing the equivalent of 50 microg Se/d), or unenriched onion meals were consumed for 12 wk. Changes in platelet glutathione peroxidase activity a

SUBMITTER: Hurst R 

PROVIDER: S-EPMC2844680 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature