Ontology highlight
ABSTRACT:
SUBMITTER: Gianni D
PROVIDER: S-EPMC2844798 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Circulation 20100301 10
<h4>Background</h4>Heart failure is a debilitating condition resulting in severe disability and death. In a subset of cases, clustered as idiopathic dilated cardiomyopathy (iDCM), the origin of heart failure is unknown. In the brain of patients with dementia, proteinaceous aggregates and abnormal oligomeric assemblies of beta-amyloid impair cell function and lead to cell death.<h4>Methods and results</h4>We have similarly characterized fibrillar and oligomeric assemblies in the hearts of iDCM pa ...[more]