Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy.

ABSTRACT:

Background

Heart failure is a debilitating condition resulting in severe disability and death. In a subset of cases, clustered as idiopathic dilated cardiomyopathy (iDCM), the origin of heart failure is unknown. In the brain of patients with dementia, proteinaceous aggregates and abnormal oligomeric assemblies of beta-amyloid impair cell function and lead to cell death.

Methods and results

We have similarly characterized fibrillar and oligomeric assemblies in the hearts of iDCM patients, pointing to abnormal protein aggregation as a determinant of iDCM. We also showed that oligomers alter myocyte Ca(2+) homeostasis. Additionally, we have identified 2 new sequence variants in the presenilin-1 (PSEN1) gene promoter leading to reduced gene and protein expression. We also show t

SUBMITTER: Gianni D 

PROVIDER: S-EPMC2844798 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature