Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology.

ABSTRACT: While the clinical and neuropathological characterization of Alzheimer's Disease (AD) is well defined, our understanding of the progression of pathologic mechanisms in AD remains unclear. Post-mortem brains from individuals who did not fulfill clinical criteria for AD may still demonstrate measurable levels of AD pathologies to suggest that they may have presented with clinical symptoms had they lived longer or are able to stave off disease progression. Comparison between such individuals and those clinically diagnosed and pathologically confirmed to have AD will be key in delineating AD pathogenesis and neuroprotection. In this study, we expression profiled laser capture microdissected non-tangle bearing neurons in 6 post-mortem brain regions that are differentially affected in the AD bra

SUBMITTER: Liang WS 

PROVIDER: S-EPMC2844804 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature