Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents.

ABSTRACT:

Objective

A major determinant of the progression from insulin resistance to the development of overt type 2 diabetes is a failure to mount an appropriate compensatory beta-cell hyperplastic response to maintain normoglycemia. We undertook the present study to directly explore the significance of the cell cycle protein cyclin D2 in the expansion of beta-cell mass in two different models of insulin resistance.

Research design and methods

We created compound knockouts by crossing mice deficient in cyclin D2 (D2KO) with either the insulin receptor substrate 1 knockout (IRS1KO) mice or the insulin receptor liver-specific knockout mice (LIRKO), neither of which develops overt diabetes on its own because of robust compensatory beta-cell hyperplasia. We phenotyped the double knockou

SUBMITTER: Georgia S 

PROVIDER: S-EPMC2844846 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature