Determinants of impaired fasting glucose versus glucose intolerance in polycystic ovary syndrome.

ABSTRACT:

Objective

To determine insulin resistance and response in patients with polycystic ovary syndrome (PCOS) and normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance, and combined glucose intolerance (CGI).

Research design and methods

In this cross-sectional study, 143 patients with PCOS (diagnosed on the basis of National Institutes of Health criteria) underwent oral glucose tolerance testing (OGTT), and 68 patients also had frequently sampled intravenous glucose tolerance tests. Changes in plasma glucose, insulin, cardiovascular risk factors, and androgens were measured.

Results

Compared with patients with NGT, those with both IFG and CGI were significantly insulin resistant (homeostasis model assessment 3.3 +/- 0.2 vs. 6.1 +/- 0.9

SUBMITTER: Karakas SE 

PROVIDER: S-EPMC2845047 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature