Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits.

ABSTRACT:

Objective

Adiponectin, a hormone secreted by adipose tissue, is of particular interest in metabolic syndrome, because it is inversely correlated with obesity and insulin sensitivity. However, it is not known to what extent the genetics of plasma adiponectin and the genetics of obesity and insulin sensitivity are interrelated. We aimed to evaluate the heritability of plasma adiponectin and its genetic correlation with the metabolic syndrome and metabolic syndrome-related traits and the association between these traits and 10 ADIPOQ single nucleotide polymorphisms (SNPs).

Research design and methods

We made use of a family-based population, the Erasmus Rucphen Family study (1,258 women and 967 men). Heritability analysis was performed using a polygenic model. Genetic correlati

SUBMITTER: Henneman P 

PROVIDER: S-EPMC2845050 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature