Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies.

ABSTRACT:

Background

Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular abnormalities display profoundly different global gene expression profiles. However, it is largely unknown whether such subtype-specific leukemic signatures are unique or if they are active also in non-hematopoietic normal tissues or in other human cancer types.

Methods

Using gene set enrichment analysis, we systematically explored whether the transcriptional programs in childhood acute lymphoblastic leukemia (ALL) and myeloid leukemia (AML) were significantly similar to those in different flow-sorted subpopulations of normal hematopoietic cells (n = 8), normal non

SUBMITTER: Andersson A 

PROVIDER: S-EPMC2845086 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature