Identical repeated backbone of the human genome.

ABSTRACT:

Background

Identical sequences with a minimal length of about 300 base pairs (bp) have been involved in the generation of various meiotic/mitotic genomic rearrangements through non-allelic homologous recombination (NAHR) events. Genomic disorders and structural variation, together with gene remodelling processes have been associated with many of these rearrangements. Based on these observations, we identified and integrated all the 100% identical repeats of at least 300 bp in the NCBI version 36.2 human genome reference assembly into non-overlapping regions, thus defining the Identical Repeated Backbone (IRB) of the reference human genome.

Results

The IRB sequences are distributed all over the genome in 66,600 regions, which correspond to approximately 2% of the total NCBI h

SUBMITTER: Zepeda-Mendoza CJ 

PROVIDER: S-EPMC2845111 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature