Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.

ABSTRACT: A functional variant in the Histamine N-Methyltransferase gene (HNMT - rs11558538) resulting in a threonine to isoleucine substitution (Thr105Ile) has been shown to impair histamine degradation. Two recent studies reported that the threonine allele of this polymorphism might be a risk factor for Parkinson disease (PD) and essential tremor (ET) development. Although PD and ET are considered different entities, they share some clinical and pathological features, suggesting a possible joint etiology. In this study we assess the role of the Thr105Ile variant in PD and ET development, genotyping the variant in a North American Caucasian PD and ET case-control series. Statistical analysis did not identify any significant association between this variant and PD or ET; therefore, our findings do n

SUBMITTER: Keeling BH 

PROVIDER: S-EPMC2845175 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature