Association between a literature-based genetic risk score and cardiovascular events in women.

ABSTRACT:

Context

While multiple genetic markers associated with cardiovascular disease have been identified by genome-wide association studies, their aggregate effect on risk beyond traditional factors is uncertain, particularly among women.

Objective

To test the predictive ability of a literature-based genetic risk score for cardiovascular disease.

Design, setting, and participants

Prospective cohort of 19,313 initially healthy white women in the Women's Genome Health Study followed up over a median of 12.3 years (interquartile range, 11.6-12.8 years). Genetic risk scores were constructed from the National Human Genome Research Institute's catalog of genome-wide association study results published between 2005 and June 2009.

Main outcome measure

Incident myocardial inf

SUBMITTER: Paynter NP 

PROVIDER: S-EPMC2845522 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature