Molecular characterisation of virulence graded field isolates of myxoma virus.

ABSTRACT:

Background

Myxoma virus (MV) has been endemic in Europe since shortly after its deliberate release in France in 1952. While the emergence of more resistant hosts and more transmissible and attenuated virus is well documented, there have been relatively few studies focused on the sequence changes incurred by the virus as it has adapted to its new host. In order to identify regions of variability within the MV genome to be used for phylogenetic studies and to try to investigate causes of MV strain attenuation we have molecularly characterised nine strains of MV isolated in Spain between the years 1992 and 1995 from wide ranging geographic locations and which had been previously graded for virulence by experimental infection of rabbits.

Results

The findings reported here show t

SUBMITTER: Dalton KP 

PROVIDER: S-EPMC2845566 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature